Penciclovir is Lectroject's up the sleeve alternative herpes treatment for acyclovir resistant strains
Denavir FDA approved prescription medication used in conjunction with lectroject for the treatment of herpes I and II.
It received its FDA approval in 1996. Denavir is a registered trademark of Novartis Consumer Health, Inc.
Denavir is the active metabolite of the oral product famciclovir. The more favorable results observed with topical penciclovir versus topical acyclovir for the treatment of herpes labialis may be due to the longer intracellular half-life of penciclovir in HSV-infected cells. Used to treat recurrent cold sores on the lips and face.
Denavir and Vectavir are brand names of Penciclovir
About penciclovir: Penciclovir, is a potent and selective inhibitor of many human herpes-viruses. Studies show that Penciclovir triphosphate is more stable than acyclovir triphosphate in HSV-infected cells. Also the levels of penciclovir triphosphate in infected cells are much higher than the levels of acyclovir triphosphate, resulting in an intracellular half-life that is between 10 and 20 fold longer..
How does it work? Vectavir is an antiviral medicine which is used to treat certain viral infections. It acts by preventing the production of viral genetic material (DNA), which is required for the reproduction and survival of the virus. Vectavir itself does not kill the virus, but by stopping it from reproducing, the virus is present in lower numbers. The lower numbers mean that the body's immune system can more easily overcome the virus.
Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form. The monophosphate form of the drug is then converted to penciclovir triphosphate by cellular kinases. The intracellular triphosphate of penciclovir is retained in vitro inside HSV-infected cells for 10-20 hours, compared with 0.7-1 hour for acyclovir. in vitro studies show that penciclovir triphosphate selectively inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. Inhibition of DNA synthesis of virus-infected cells inhibits viral replication. In cells not infected with HSV, DNA synthesis is unaltered. Resistant mutants of HSV can occur from qualitative changes in viral thymidine kinase or DNA polymerase.
The best time to begin treatment is in the early itching tingle stage. The medication attacks the DNA of the virus, If the virus is present Denavir will affect it. With or without outbreak it will still help destroy the virus.
It's better not to wait for an outbreak as, at that time your immune system is depressed and the virus is at it's most potent. The earlier in the disease process that treatment begins, the more effective are the results.
You dont have to have the blisters present, lectroject denavir treatment during outbreaks is to shorten the attack but treatment between attacks could help to abort the attack. The Lectroject device is designed to reduce outbreaks and hopefully, destroys the virus.
There have been encouraging reports from the US that penciclovir is much more effective than acyclovir. Having said that, three of the sources we have used as references for this page (Femiano 2001, Lin 2002, McKeough 2001 ) have each studied the head-to-head effectiveness of acyclovir cream (the compound found in Zovirax) and penciclovir cream (the compound found in Denavir) in the treatment of cold sores. The conclusions drawn by all three of these studies suggest that penciclovir cream (Denavir) is the more effective medication.
Acyclovir appears to be losing its effectiveness in the same way as Penicillin. If you do proof resistant to acyclovir, then the medication of choice is penciclovir (Denavir).